Hepatitis B RNA and Core-Related Antigen Provide Value Beyond DNA in Evaluating e But Not Surface Antigen Clearance

Clin Gastroenterol Hepatol. 2023 Jul;21(7):1957-1959. doi: 10.1016/j.cgh.2022.06.019. Epub 2022 Jul 16.


In chronic hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) clearance are important milestones toward immune control.1 A drop in HBV DNA is an established correlate of both HBeAg and HBsAg clearance.2 We evaluated changes in HBV RNA and hepatitis B core-related antigen (HBcrAg) levels, markers of transcriptional activity of covalently closed circular DNA (cccDNA),3,4 with HBeAg and HBsAg clearance, and compared them with changes in HBV DNA level among adult participants in the Hepatitis B Research Network (HBRN).

MeSH terms

  • Adult
  • Antigens, Surface / therapeutic use
  • Antiviral Agents / therapeutic use
  • Biomarkers
  • DNA, Circular / therapeutic use
  • DNA, Viral
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens / genetics
  • Hepatitis B e Antigens
  • Hepatitis B virus / genetics
  • Hepatitis B* / drug therapy
  • Hepatitis B, Chronic* / drug therapy
  • Humans
  • RNA / therapeutic use


  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
  • DNA, Viral
  • Antigens, Surface
  • RNA
  • Hepatitis B Core Antigens
  • DNA, Circular
  • Biomarkers
  • Antiviral Agents