Age- and sex-related study of hepatitis B virus chronic carrier state in infants from an endemic area (Senegal)

J Med Virol. 1987 May;22(1):1-5. doi: 10.1002/jmv.1890220102.


This report concerns hepatitis B virus (HBV) infections observed in 155 infants from Senegal, studied with a view to determining the factors involved in development of the chronic carrier state. A chronic carrier state was observed in 50.3% of the infants. This study confirms that the risk of chronic carriage is linked to age. This risk declines very rapidly with age, falling from 82% in infants under 6 months old, to 15% in children between the ages of 2 and 3 years. Spontaneous elimination of hepatitis B surface antigen (HBsAg) is uncommon in HBsAg carriers during childhood. The difference observed in chronic carriage between males and females is due to a difference in susceptibility of the two sexes to the development of the chronic carrier state: HBV infections (before 2 years of age) lead to a chronic carriage in 77% of males as against 50% of females. These conclusions are important in view of the immunisation programs being carried out against hepatitis B virus in endemic areas. For a maximum efficacy, vaccination must be carried out at birth, or shortly afterwards.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Carrier State / epidemiology*
  • Child
  • Child, Preschool
  • Female
  • Hepatitis B / epidemiology*
  • Hepatitis B Antibodies / analysis
  • Hepatitis B Surface Antigens / analysis
  • Humans
  • Infant
  • Male
  • Risk
  • Senegal
  • Sex Factors


  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens