Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats

J Nutr Sci Vitaminol (Tokyo). 1986 Dec;32(6):613-22. doi: 10.3177/jnsv.32.613.

Abstract

Effects of tea catechins (tannins) on lipid metabolism were studied in male weanling rats fed a 25% casein diet containing 15% lard and 1% cholesterol for 28 days. Crude tea catechins prepared from green tea powder were supplemented at a 1% and 2% of the lard-cholesterol diet. The addition of 2% tea catechins slightly depressed growth but at the 1% level was without effect. Tea catechins decreased plasma total cholesterol, cholesterol ester, total cholesterol--HDL-cholesterol (VIDL-+LDL-cholesterol) and atherogenic index (VLDL-+LDL-cholesterol/HDL-cholesterol). Hematocrit and plasma glucose were not altered by the addition of tea catechins. The liver weight, liver total lipids and cholesterol concentrations in rats fed the lard-cholesterol diet increased more than in the control rats, but the addition of tea catechins to the lard-cholesterol diet decreased those parameters. Tea catechin supplementation increased fecal excretion of total lipids and cholesterol. The results demonstrate that tea catechins exert a hypocholesterolemic effect in cholesterol-fed rats.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Catechin / pharmacology*
  • Cholesterol / blood*
  • Cholesterol / metabolism
  • Eating / drug effects
  • Feces / analysis
  • Lipid Metabolism
  • Liver / anatomy & histology
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Organ Size / drug effects
  • Rats
  • Rats, Inbred Strains
  • Tea / analysis*

Substances

  • Tea
  • Catechin
  • Cholesterol