Engineering stem cell therapeutics for cardiac repair

Jun Fang; Jennifer J Li; Xintong Zhong; Yue Zhou; Randall J Lee; Ke Cheng; Song Li

doi:10.1016/j.yjmcc.2022.06.013

Engineering stem cell therapeutics for cardiac repair

J Mol Cell Cardiol. 2022 Oct:171:56-68. doi: 10.1016/j.yjmcc.2022.06.013. Epub 2022 Jul 18.

Authors

Jun Fang¹, Jennifer J Li², Xintong Zhong³, Yue Zhou³, Randall J Lee⁴, Ke Cheng⁵, Song Li⁶

Affiliations

¹ Department of Bioengineering, Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA; School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: fang.jun@sjtu.edu.cn.
² Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA; Department of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
³ School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200240, China.
⁴ Department of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA 94143, USA.
⁵ Department of Biomedical Engineering, North Carolina State University, NC, USA.
⁶ Department of Bioengineering, Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, California 90095, USA. Electronic address: songli@ucla.edu.

PMID: 35863282
DOI: 10.1016/j.yjmcc.2022.06.013

Abstract

Cardiovascular disease is the leading cause of death in the world. Stem cell-based therapies have been widely investigated for cardiac regeneration in patients with heart failure or myocardial infarction (MI) and surged ahead on multiple fronts over the past two decades. To enhance cellular therapy for cardiac regeneration, numerous engineering techniques have been explored to engineer cells, develop novel scaffolds, make constructs, and deliver cells or their derivatives. This review summarizes the state-of-art stem cell-based therapeutics for cardiac regeneration and discusses the emerged bioengineering approaches toward the enhancement of therapeutic efficacy of stem cell therapies in cardiac repair. We cover the topics in stem cell source and engineering, followed by stem cell-based therapies such as cell aggregates and cell sheets, and biomaterial-mediated stem cell therapies such as stem cell delivery with injectable hydrogel, three-dimensional scaffolds, and microneedle patches. Finally, we discuss future directions and challenges of engineering stem cell therapies for clinical translation.

Keywords: Cardiovascular bioengineering; Genetic engineering; Micro/nanotechnology; Stem cell engineering.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials
Heart*
Humans
Hydrogels
Stem Cells
Tissue Engineering* / methods

Substances

Biocompatible Materials
Hydrogels