Decreased Risk of Coronavirus Disease 2019-Related Hospitalization Associated With the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2

Jessica P Ridgway; Samuel Tideman; Bill Wright; Ari Robicsek

doi:10.1093/ofid/ofac288

Decreased Risk of Coronavirus Disease 2019-Related Hospitalization Associated With the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2

Open Forum Infect Dis. 2022 Jun 15;9(7):ofac288. doi: 10.1093/ofid/ofac288. eCollection 2022 Jul.

Authors

Jessica P Ridgway¹, Samuel Tideman², Bill Wright², Ari Robicsek²

Affiliations

¹ Department of Medicine, University of Chicago, Chicago, Illinois, USA.
² Providence Research Network, Renton, Washington, USA.

Abstract

Among 134 223 patients with coronavirus disease 2019 (COVID-19), we assessed how risk of hospitalization changed at different intervals in the pandemic, controlling for prior COVID-19 immunity. In multivariable analysis, outpatients with COVID-19 during the Omicron-predominant time period had significantly lower odds of hospitalization compared to pre-Delta (adjusted odds ratio, 0.26 [95% confidence interval, .22-.32]).

Keywords: COVID-19; Omicron variant; SARS-CoV-2.