Sweet sensors support stressed cell survival

PLoS Biol. 2022 Jul 22;20(7):e3001705. doi: 10.1371/journal.pbio.3001705. eCollection 2022 Jul.


Gustatory receptors (Grs) are well known for their functions in sensory neurons in detecting food and toxins. An intriguing new study in PLOS Biology provides evidence for a role for Grs in Drosophila epithelia in protecting stressed cells from proteotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Survival
  • Drosophila Proteins* / metabolism
  • Drosophila* / metabolism
  • Epithelial Cells / metabolism
  • Proteostasis
  • Receptors, Cell Surface / metabolism
  • Taste / physiology


  • Drosophila Proteins
  • Receptors, Cell Surface

Grants and funding

N.J.H. is supported by a Human Frontier Science Program Long-Term Postdoctoral Fellowship (LT-0003/2022-L). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.