Sweet sensors support stressed cell survival

PLoS Biol. 2022 Jul 22;20(7):e3001705. doi: 10.1371/journal.pbio.3001705. eCollection 2022 Jul.

Abstract

Gustatory receptors (Grs) are well known for their functions in sensory neurons in detecting food and toxins. An intriguing new study in PLOS Biology provides evidence for a role for Grs in Drosophila epithelia in protecting stressed cells from proteotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Survival
  • Drosophila Proteins* / metabolism
  • Drosophila* / metabolism
  • Epithelial Cells / metabolism
  • Proteostasis
  • Receptors, Cell Surface / metabolism
  • Taste / physiology

Substances

  • Drosophila Proteins
  • Receptors, Cell Surface

Grants and funding

N.J.H. is supported by a Human Frontier Science Program Long-Term Postdoctoral Fellowship (LT-0003/2022-L). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.