TOPBPing up DSBs with PARylation

Mol Cell. 2022 Jul 21;82(14):2538-2540. doi: 10.1016/j.molcel.2022.06.038.


Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIβ-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • DNA Topoisomerases, Type II / genetics
  • Homologous Recombination
  • Poly ADP Ribosylation
  • S Phase


  • DNA Topoisomerases, Type II