TOPBPing up DSBs with PARylation

Shrabasti Roychoudhury; Dipanjan Chowdhury

doi:10.1016/j.molcel.2022.06.038

TOPBPing up DSBs with PARylation

Mol Cell. 2022 Jul 21;82(14):2538-2540. doi: 10.1016/j.molcel.2022.06.038.

Authors

Shrabasti Roychoudhury¹, Dipanjan Chowdhury²

Affiliations

¹ Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
² Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: dipanjan_chowdhury@dfci.harvard.edu.

PMID: 35868254
DOI: 10.1016/j.molcel.2022.06.038

Abstract

Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIβ-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

DNA Breaks, Double-Stranded*
DNA Repair*
DNA Topoisomerases, Type II / genetics
Homologous Recombination
Poly ADP Ribosylation
S Phase

Substances

DNA Topoisomerases, Type II

Grants and funding

R01 CA264900/CA/NCI NIH HHS/United States