Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Mol Metab. 2022 Jul 21;101557. doi: 10.1016/j.molmet.2022.101557. Online ahead of print.


The gut microbiome influences host physiology and disease by interacting directly with cells in the intestine or by producing molecules that enter the host circulation. Since there are a large number of microbial species and since the gut microbiome composition is influenced by many factors, it is challenging to understand the mechanisms involved. One approach involves simultaneously examining individuals in populations for gut microbiome composition, molecular traits using "omics" technologies, such as circulating metabolites quantified using mass spectrometry, and clinical traits. Thus far, such studies in both mice and humans have led to the identification of numerous metabolites that mediate gut microbiome-host interactions. We discuss these findings as well as future applications of the approach.

Keywords: Intestine; Microbiome composition; Microbiome-derived metabolites; Systems genetics.

Publication types

  • Review