Autoimmune thyroiditis and celiac disease do not worsen endothelial function in subjects with type 1 diabetes: an observational study

Martina Parise; Antonio Cutruzzolà; Faustina Barbara Scavelli; Claudio Carallo; Agostino Gnasso; Concetta Irace

doi:10.1186/s13098-022-00877-y

Autoimmune thyroiditis and celiac disease do not worsen endothelial function in subjects with type 1 diabetes: an observational study

Diabetol Metab Syndr. 2022 Jul 23;14(1):103. doi: 10.1186/s13098-022-00877-y.

Authors

Martina Parise^#¹, Antonio Cutruzzolà^#², Faustina Barbara Scavelli³, Claudio Carallo³, Agostino Gnasso², Concetta Irace⁴

Affiliations

¹ Department of Health Science, University Magna Græcia, Viale Europa, Località Germaneto, Catanzaro, Italy.
² Department of Clinical and Experimental Medicine, University Magna Græcia, Catanzaro, Italy.
³ Azienda Ospedaliero-Universitaria Mater Domini, Catanzaro, Italy.
⁴ Department of Health Science, University Magna Græcia, Viale Europa, Località Germaneto, Catanzaro, Italy. irace@unicz.it.

^# Contributed equally.

Abstract

Background: Type 1 diabetes (T1D) is frequently associated with autoimmune thyroiditis (AT) and coeliac disease (CD). Whether the coexistence of multiple autoimmune diseases increases cardiovascular risk is uncertain. We evaluated the effects of AT and CD on arterial wall thickening and endothelial function in patients with T1D.

Methods: This observational study analyzed data from T1D patients regularly followed by the Diabetes Care Centre. Clinical and biochemical characteristics and micro and macrovascular complications were collected from the electronic medical records. All subjects performed Echo-Doppler to evaluate Intima-Media Thickness (IMT) of the common carotid artery (CCA) and endothelial function by the flow-mediated dilation (FMD) technique. The statistical analyses were performed by SPSS for Macintosh. Comparison between means was performed using the t-test for unpaired data and the Mann-Whitney U test. The ANalysis Of VAriance and the Tukey posthoc test were applied to compare patients with and without other autoimmune diseases, and control subjects. The p-value for statistical significance was set at p < 0.05.

Results: A total of 110 patients were enrolled. Among these, 69 had T1D and 41 T1D and AT and or CD, of whom 33 AT, 7 CD, and 1 both AT and CD. The mean age was 35 years, mean HbA1c was 7.6%, and mean diabetes duration 18 years. The IMT of the CCA was not significantly different between T1D patients with and without concomitant autoimmune diseases (with AT and CD: right CCA 603 ± 186 µ, left 635 ± 175 µ; without AT and CD: right CCA 611 ± 176 µ, left CCA 631 ± 200 µ). FMD was also comparable between T1D groups, with AT and CD 7.9 ± 4.2%; without AT and CD 8.8 ± 4.4%.

Conclusion: Patients with T1D and concomitant AT and or CD show no worse morphological or functional vascular damage, evaluated by CCA IMT and brachial artery flow-mediated dilation, than patients with T1D alone.

Keywords: Atherosclerosis; Autoimmune thyroiditis; Coeliac disease; Endothelial function; Reactive hyperemia flow mediated dilation; Type 1 diabetes.