Prevalence of ras gene mutations in human colorectal cancers

Nature. 1987 May 28-Jun 3;327(6120):293-7. doi: 10.1038/327293a0.

Abstract

A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoma / genetics
  • Adenoma / pathology
  • Carcinoma / genetics
  • Carcinoma / pathology
  • Codon
  • Colonic Neoplasms / genetics*
  • Colonic Neoplasms / pathology
  • DNA / genetics
  • Humans
  • Mutation*
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Rectal Neoplasms / genetics*
  • Rectal Neoplasms / pathology

Substances

  • Codon
  • DNA