Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Angela Dramowski; Marina Aucamp; Emily Beales; Adrie Bekker; Mark Frederic Cotton; Felicity C Fitzgerald; Appiah-Korang Labi; Neal Russell; Jonathan Strysko; Andrew Whitelaw; Susan Coffin

doi:10.3389/fped.2022.919403

Healthcare-Associated Infection Prevention Interventions for Neonates in Resource-Limited Settings

Front Pediatr. 2022 Jul 7:10:919403. doi: 10.3389/fped.2022.919403. eCollection 2022.

Authors

Affiliations

¹ Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
² Infection Prevention and Control Service, Mowbray Maternity Hospital, Cape Town, South Africa.
³ Center for Neonatal and Pediatric Infection, St George's University of London, London, United Kingdom.
⁴ Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
⁵ Department of Medical Microbiology, University of Ghana Medical School, Accra, Ghana.
⁶ Department of Paediatric and Adolescent Health, Princess Marina Hospital, Gaborone, Botswana.
⁷ Department of Global Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
⁸ Division of Medical Microbiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
⁹ National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.
¹⁰ Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Abstract

Healthcare-associated infections (HAIs) and antimicrobial-resistant (AMR) infections are leading causes of neonatal morbidity and mortality, contributing to an extended hospital stay and increased healthcare costs. Although the burden and impact of HAI/AMR in resource-limited neonatal units are substantial, there are few HAI/AMR prevention studies in these settings. We reviewed the mechanism of action and evidence supporting HAI/AMR prevention interventions, including care bundles, for hospitalized neonates in low- and middle-income countries (LMIC).

Keywords: antimicrobial resistance; care bundles; healthcare-associated infection; neonate; resource-limited.

Publication types

Review

Grants and funding

K43 TW010682/TW/FIC NIH HHS/United States