The annual special issue of Evidence-Based Oncology™, a publication of The American Journal of Managed Care® (AJMC), features coverage of the 2022 Annual Meeting of the American Society of Clinical Oncology, held June 3-7, 2022, in Chicago, Illinois. Clinical trials presented during the meeting and summarized in the issue include DESTINY-Breast04, DETERMINATION, SHINE, and ECHELON-1. The issue features coverage from sessions addressing current issues in health policy and cancer care delivery, such as improving diversity in clinical trials and managing financial toxicity. Sections of the special issue include Advancing Health Equity, Breast Cancer, Solid Tumors, Blood Cancers, and Health Policy & Delivery. A final section features clinical findings presented by scientists affiliated with Strategic Alliance Partners of AJMC. Each issue section includes an interview with a key opinion leader participating in the meeting.