Lysosomal Potassium Channels

Handb Exp Pharmacol. 2023:278:127-152. doi: 10.1007/164_2022_600.

Abstract

Lysosomes are acidic membrane-bound organelles that use hydrolytic enzymes to break down material through pathways such as endocytosis, phagocytosis, mitophagy, and autophagy. To function properly, intralysosomal environments are strictly controlled by a set of integral membrane proteins such as ion channels and transporters. Potassium ion (K+) channels are a large and diverse family of membrane proteins that control K+ flux across both the plasma membrane and intracellular membranes. In the plasma membrane, they are essential in both excitable and non-excitable cells for the control of membrane potential and cell signaling. However, our understanding of intracellular K+ channels is very limited. In this review, we summarize the recent development in studies of K+ channels in the lysosome. We focus on their characterization, potential roles in maintaining lysosomal membrane potential and lysosomal function, and pathological implications.

Keywords: BK channel; Lysosome; Potassium channel; TMEM175.

Publication types

  • Review

MeSH terms

  • Cell Membrane / metabolism
  • Endocytosis
  • Humans
  • Ion Channels
  • Lysosomes* / metabolism
  • Potassium Channels*

Substances

  • Potassium Channels
  • Ion Channels