Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation

Pediatr Pulmonol. Mar-Apr 1987;3(2):86-9. doi: 10.1002/ppul.1950030209.

Abstract

We prospectively evaluated bronchial washings from 45 patients aged 1 month to 25 years (mean 3.3 years) for the presence of lipid-laden macrophages. By grading the amount of intracellular oil-red-O-positive material, we determined a semiquantitative lipid-laden macrophage index for each patient. All patients observed to be definite aspirators (n = 22) had indexes greater than or equal to 86 (mean +/- SD, 139 +/- 46). All patients with no clinical suspicion of aspiration (n = 23) had indexes less than or equal to 72 (mean +/- SD, 21 +/- 20). Our results suggest that simply sighting lipid-laden macrophages in a nonspecific finding, but quantitation of these cells may be a very good test for recurrent aspiration of food substances in children. This test appears to be more sensitive than radiographic studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bronchoscopy
  • Child
  • Child, Preschool
  • Esophagus / diagnostic imaging
  • Humans
  • Infant
  • Lipids / analysis
  • Lung / diagnostic imaging
  • Macrophages / pathology*
  • Pneumonia, Aspiration / pathology*
  • Prospective Studies
  • Radiography
  • Recurrence

Substances

  • Lipids