Bronchoalveolar-Lavage-Derived Fibroblast Cell Lines Provide Tools for Investigating Various Interstitial Lung Diseases

Siri Lehtonen; Riitta Kaarteenaho

doi:10.3390/cells11142226

Bronchoalveolar-Lavage-Derived Fibroblast Cell Lines Provide Tools for Investigating Various Interstitial Lung Diseases

Cells. 2022 Jul 18;11(14):2226. doi: 10.3390/cells11142226.

Authors

Siri Lehtonen^{1

2}, Riitta Kaarteenaho^{3

4}

Affiliations

¹ PEDEGO Research Unit, University of Oulu, POB 8000, FIN-90014 Oulu, Finland.
² Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital, POB 10, FIN-90029 Oulu, Finland.
³ Research Unit of Internal Medicine, University of Oulu, POB 8000, FIN-90014 Oulu, Finland.
⁴ Center of Internal Medicine and Respiratory Medicine, Medical Research Center Oulu, Oulu University Hospital, POB 10, FIN-90029 Oulu, Finland.

Abstract

Bronchoalveolar lavage (BAL) is an important diagnostic and research tool for the investigation of various lung diseases. In addition to inflammatory and epithelial cells, BAL fluid may contain a small number of stromal cells, such as fibroblasts. During the past 30 years, a number of research groups have cultured BAL-derived fibroblasts for several passages in vitro. In addition to fibroblasts, these cultures have been reported to contain fibrocytes, myofibroblasts, and stem cells. We aim to present a summary of studies that have cultured stromal cells from BAL fluid.

Keywords: BAL-derived cell culture; fibroblast; idiopathic pulmonary fibrosis; myofibroblast.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bronchoalveolar Lavage
Cell Line
Fibroblasts / metabolism
Humans
Lung Diseases, Interstitial* / metabolism
Therapeutic Irrigation*

Grants and funding

This research was funded by the Research Foundation of North Finland and a state subsidy of the Oulu University Hospital.