Hematological and biochemical markers in determining the diagnosis and stage prediction of endometrial cancer

Ginekol Pol. 2023;94(4):283-290. doi: 10.5603/GP.a2022.0038. Epub 2022 Jul 27.


Objectives: To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish whether hematological and biochemical parameters may be useful in predicting the stages of endometrial malignancy and in differentiating premalignant and malignant endometrial changes.

Material and methods: A retrospective study included 100 patients (70 with endometrial carcinoma diagnosis and 30 with atypical hyperplasia). We compared hematological and biochemical parameters in both groups.

Results: CRP, granulocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) are statistically significantly higher in patients with malignant changes. Lymphocyte count is statistically significantly lower in patients with malignant changes. Platelet count is statistically significantly lower in patients with stages I and II in comparison to patients with higher disease stage. NLR and PLR have good discriminatory power for carcinoma presence. Patients with advanced changes have statistically significantly higher CRP values, higher granulocyte and platelet count, as well as higher values of NLR and PLR, and statistically significantly lower values of lymphocytes and MPV in comparison to benign changes.

Conclusions: There is a possibility of using hematological and biochemical parameters in the assessment of endometrial changes as well as in the prediction of stages, in confirmed malignant changes of the endometrium.

Keywords: biochemical parameters; endometrial cancer; hematological parameters; stage.

MeSH terms

  • Biomarkers
  • Blood Platelets / pathology
  • Endometrial Neoplasms* / diagnosis
  • Endometrial Neoplasms* / pathology
  • Female
  • Humans
  • Lymphocyte Count
  • Lymphocytes / pathology
  • Neutrophils / pathology
  • Precancerous Conditions*
  • Prognosis
  • Retrospective Studies


  • Biomarkers