CT, MRI, and radiomics studies of liver metastasis histopathological growth patterns: an up-to-date review

Shenglin Li; Zhengxiao Li; Xiaoyu Huang; Peng Zhang; Juan Deng; Xianwang Liu; Caiqiang Xue; Wenjuan Zhang; Junlin Zhou

doi:10.1007/s00261-022-03616-z

CT, MRI, and radiomics studies of liver metastasis histopathological growth patterns: an up-to-date review

Abdom Radiol (NY). 2022 Oct;47(10):3494-3506. doi: 10.1007/s00261-022-03616-z. Epub 2022 Jul 27.

Authors

Shenglin Li^#^{1

2

3

4}, Zhengxiao Li^#^{1

2

3

4}, Xiaoyu Huang^{1

2

3

4}, Peng Zhang⁵, Juan Deng^{1

2

3

4}, Xianwang Liu^{1

2

3

4}, Caiqiang Xue^{1

2

3

4}, Wenjuan Zhang^{1

2

3

4}, Junlin Zhou^{6

7

8

9}

Affiliations

¹ Department of Radiology, Lanzhou University Second Hospital, Cuiyingmen No.82, Chengguan District, Lanzhou, 730030, China.
² Second Clinical School, Lanzhou University, Lanzhou, China.
³ Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China.
⁴ Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, China.
⁵ Department of Pathology, Lanzhou University Second Hospital, Cuiyingmen No.82, Chengguan District, Lanzhou, 730030, China.
⁶ Department of Radiology, Lanzhou University Second Hospital, Cuiyingmen No.82, Chengguan District, Lanzhou, 730030, China. ery_zhoujl@lzu.edu.cn.
⁷ Second Clinical School, Lanzhou University, Lanzhou, China. ery_zhoujl@lzu.edu.cn.
⁸ Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China. ery_zhoujl@lzu.edu.cn.
⁹ Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, China. ery_zhoujl@lzu.edu.cn.

^# Contributed equally.

PMID: 35895118
DOI: 10.1007/s00261-022-03616-z

Abstract

The histopathological growth patterns (HGPs) of liver metastases (LMs) are independently associated with the long-term prognosis of the primary tumor, with different HGPs predicting different patient outcomes and clinical treatment decisions. Non-invasive imaging biomarkers for stratification of HGPs are beneficial for treatment monitoring, evaluation of efficacy, and prognosis prediction of LMs. This review describes the state of research regarding computed tomography (CT), magnetic resonance imaging (MRI), and radiomics imaging biomarkers for LM-HGPs; discusses the advantages of CT, MRI, and radiomics for classification of LM-HGPs; and provides a reference for the stratification of LM-HGPs. Finally, the difficulties and deficiencies of CT, MRI, and radiomics in LM-HGP research are summarized along with the proposed directions for future research.

Keywords: CT; Histopathological growth patterns; Liver metastasis; MRI; Radiomics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Liver Neoplasms* / diagnostic imaging
Liver Neoplasms* / secondary
Magnetic Resonance Imaging
Prognosis
Retrospective Studies
Tomography, X-Ray Computed / methods