The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis

BMC Musculoskelet Disord. 2022 Jul 27;23(1):717. doi: 10.1186/s12891-022-05657-3.


Objectives: To investigate longitudinal relationship between serum uric acid (SUA) and disease activity among Chinese males with axial spondyloarthritis (axSpA).

Methods: Two-year data from the NASA study cohort of male patients with axial spondyloarthritis were analyzed. Patients global assessment of disease activity (PtGA), BASDAI, ASDAS-CRP, BASFI, and SF-36 were used as the outcomes. The autoregressive Generalized Estimation Equation (GEE) model was used to investigate the longitudinal relationship between SUA and the above outcomes. Age and gender and symptom duration were tested as effect modifiers or confounders.

Results: In total, 102 male axSpA patients were included, 33.3% of who were hyperuricemia at baseline. Over time,serum uric acid levels associated with the global assessment of patient global assessment of disease activity (PtGA)[P=0.041, β=-2.059,95%CI(-4.032, -0.086)], SF-36: Vitality (VT) [P=0.01, β=1.751, 95%CI (0.415,3.087)], SF-36: Social Functioning (SF)[P=0.002, β= 2.968,95%CI (1.067,4.869)]). And these relationgships were independent of age, symptom duration, baseline uric acid levels, and medication use.

Conclusions: In summary, SUA levels is longitudinally related to PtGA and mental health assessment. Age, gender and symptom duration do not have an impact on the relationships.

Keywords: Axial spondyloarthritis; Longitudinally; Patient global assessment; SF-36; Serum Uric acid.

MeSH terms

  • Axial Spondyloarthritis*
  • Cohort Studies
  • Humans
  • Male
  • Severity of Illness Index
  • Spondylarthritis* / diagnosis
  • Spondylitis, Ankylosing* / diagnosis
  • Uric Acid


  • Uric Acid