Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

Int J Mol Sci. 2022 Jul 26;23(15):8253. doi: 10.3390/ijms23158253.


Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a "window" to the mother's future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother's future.

Keywords: gestational diabetes mellitus; metabolic syndrome; microbiome; obesity; preeclampsia; pregnant women; probiotic supplementation.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Diabetes, Gestational* / metabolism
  • Diabetes, Gestational* / prevention & control
  • Female
  • Gastrointestinal Microbiome*
  • Gestational Weight Gain*
  • Humans
  • Metabolic Syndrome* / prevention & control
  • Pregnancy
  • Probiotics* / therapeutic use
  • Weight Gain

Grant support

This research was funded by the Medical University of Lublin, grant number 332,336.