Association Between Globulin and Diabetic Nephropathy in Type2 Diabetes Mellitus Patients: A Cross-Sectional Study

Front Endocrinol (Lausanne). 2022 Jul 8:13:890273. doi: 10.3389/fendo.2022.890273. eCollection 2022.


Background: With the development of economy, the living standard of people all over the world has been greatly improved, and the incidence of diabetes is also increasing. Many people with diabetes also develop other complications that reduce their quality of life. Diabetic nephropathy is a common complication of type2 diabetes. Understanding the related factors of diabetic nephropathy is greatly significant to control the occurrence of diabetic nephropathy and improve patient's life quality.

Data and methods: Data were collected from 2009 to 2018 in NHANES. Curve fitting graph was performed to investigate the association between globulin (GLB) and diabetic nephropathy(DN). Four logistic regression models were conducted to control the potential confounding factors. Subgroup analysis was carried out to assess the stability of results.

Results: GLB was positively correlated with the occurrence of DN after controlling for potential confounders. Higher GLB was associated with an increased risk of diabetic nephropathy [odds ratio(OR), 1.10; 95% confidence interval (CI), 1.07-1.13, P < 0.001].

Conclusions: In this cross-sectional study, GLB was significant positively correlated with the occurrence of DN in patients with type2 diabetes mellitus.

Keywords: curve fitting; diabetic nephropathy; globulin; logistic regression; type 2 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2* / complications
  • Diabetic Nephropathies* / epidemiology
  • Diabetic Nephropathies* / etiology
  • Globulins*
  • Humans
  • Nutrition Surveys
  • Quality of Life


  • Globulins

Associated data

  • ChiCTR/ChiCTR2100047665