Promising effects of corticosteroid treatment in combination with antifungal agents in a patient with Aspergillus meningitis

Parisa Aziz Jalali; Ensieh Lotfali; Kamran Rezaei; Alireza Fatemi; Farzad Ashrafi; Saeed Oraee-Yazdani; Alimohammad Mirdehghan

doi:10.1002/ccr3.5993

Promising effects of corticosteroid treatment in combination with antifungal agents in a patient with Aspergillus meningitis

Clin Case Rep. 2022 Jul 25;10(7):e5993. doi: 10.1002/ccr3.5993. eCollection 2022 Jul.

Authors

Parisa Aziz Jalali¹, Ensieh Lotfali², Kamran Rezaei³, Alireza Fatemi⁴, Farzad Ashrafi⁵, Saeed Oraee-Yazdani⁶, Alimohammad Mirdehghan³

Affiliations

¹ Department of Neurology Shohada-e Tajrish Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.
² Department of Medical Parasitology and Mycology School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
³ Student Research Committee School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.
⁴ Infectious Diseases and Tropical Medicine Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.
⁵ Functional Neurosurgery Research Center Shohada-e Tajrish Neurosurgical Center of Excellence Shahid Beheshti University of Medical Sciences Tehran Iran.
⁶ Department of Neurosurgery Shohada Tajrish Comprehensive Neurosurgical Center of Excellence Shahid Beheshti University of Medical Sciences Tehran Iran.

Abstract

Although Aspergillus meningitis is poorly responsive to current guidelines for treatment, we describe a dramatic response of Aspergillus meningitis in a patient to treatment using a combination of corticosteroids with guideline's suggested antifungal agents. Administration of corticosteroids in patients with Aspergillus meningitis is rarely reported in previous studies.

Keywords: Aspergillus; aspergillosis; corticosteroid; meningitis.

Publication types

Case Reports