Early coronary angiography in patients after out-of-hospital cardiac arrest without ST-segment elevation: Meta-analysis of randomized controlled trials

Catheter Cardiovasc Interv. 2022 Sep;100(3):330-337. doi: 10.1002/ccd.30355. Epub 2022 Jul 28.


Objectives: To compare early coronary angiography to a delayed or selective approach in out-of-hospital cardiac arrest (OHCA) without ST-segment elevation of possible cardiac cause by means of meta-analysis of available randomized controlled trials (RCTs).

Methods: We searched MEDLINE and the Cochrane Central Register of Controlled Trials for RCTs comparing early with delayed or selective coronary angiography in OHCA patients of possible cardiac origin without ST-segment elevation. The primary endpoint was all-cause short-term mortality (PROSPERO CRD42021271484).

Results: The search strategy identified three RCTs enrolling a total of 1167 patients. An early invasive approach was not associated with improved short-term mortality (odds ratio 1.19, 95% confidence interval 0.94-1.52; p = 0.15). Further, no significant differences were shown with respect to the risk of severe neurological deficit, the composite of all-cause mortality or severe neurological deficit, need for renal replacement therapy due to acute renal failure, and significant bleeding at short-term follow-up.

Conclusion: Early coronary angiography in OHCA without ST-segment elevation is not superior compared to a delayed/selective approach.

Keywords: coronary angiography; out-of-hospital cardiac arrest; survival.

Publication types

  • Meta-Analysis

MeSH terms

  • Coronary Angiography / methods
  • Humans
  • Out-of-Hospital Cardiac Arrest* / diagnostic imaging
  • Out-of-Hospital Cardiac Arrest* / etiology
  • Out-of-Hospital Cardiac Arrest* / therapy
  • Percutaneous Coronary Intervention* / adverse effects
  • Randomized Controlled Trials as Topic
  • Time Factors
  • Treatment Outcome