Effects of Low Dietary Intake of Methionine, Choline or Proteins on the Biotransformation of Arsenite in the Rabbit

Toxicol Lett. 1987 Jun;37(1):41-6. doi: 10.1016/0378-4274(87)90165-2.

Abstract

The effects of 6 weeks feeding with diets low in methionine, choline, or proteins on the biotransformation and retention of 76As-labelled arsenite (0.4 mg As/kg bw) in rabbits have been studied. All test diets caused a significant decrease in the urinary excretion of dimethyl[76As]-arsinic acid, the main metabolite of inorganic arsenic. This gave rise to an increased retention of arsenic in the tissues, especially liver and lung. The test diets also caused a specific increase of the arsenic concentration in liver microsomes. The results indicate that subjects with a poor nutritional status have a lower capacity of methylating and thereby detoxifying inorganic arsenic.

MeSH terms

  • Animals
  • Arsenic / metabolism*
  • Arsenites*
  • Biotransformation
  • Choline / administration & dosage*
  • Diet*
  • Dietary Proteins / administration & dosage*
  • Male
  • Methionine / administration & dosage*
  • Methylation
  • Rabbits
  • Tissue Distribution

Substances

  • Arsenites
  • Dietary Proteins
  • Methionine
  • arsenite
  • Arsenic
  • Choline