The core competencies defined by the Accreditation Council for Graduate Medical Education merge under the 21st century skills. Technological advancements and globalisation have posed new requirements on all fronts. The 21st century skills are the 12 essential abilities for success in the internet age. Medical education has adapted the 21st century skills in all aspects. The 21st century skills are essential for producing relevant doctors in the age of internet and artificial intelligence. In this article, we present an example of teaching the anaesthesia basics by applying the 21st century skills.