Anti-inflammatory effects of resveratrol in patients with cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials

Complement Ther Med. 2022 Nov;70:102863. doi: 10.1016/j.ctim.2022.102863. Epub 2022 Jul 26.

Abstract

Background: Chronic inflammation is one of the most important factors involved in the development and progression of cardiovascular disease (CVDs). Accumulating evidence has described the effect of resveratrol, a natural polyphenolic compound, on biomarkers of inflammation among patients with CVDs; however, findings are controversial. Here we performed a systematic review and meta-analysis of randomized controlled trials to evaluate the effect of resveratrol supplements on TNF-α, IL-6, and CRP levels in CVDs patients.

Methods: Online research was conducted in the following database: MEDLINE, EMBASE, Cochrane Library, Web of Science databases, and Scopus. This systematic review and meta-analysis were conducted to investigate the effects of resveratrol supplements on inflammatory biomarkers among patients with CVDs. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V3 software.

Results: Six RCTs met the inclusion criteria and were selected for the current meta-analysis. Our results demonstrated that resveratrol significantly decreases serum levels of CRP (MD = -0.63, 95 % CI: -0.1.13, -0.12; p = 0.01), and TNF-α (MD = -0.55, 95 % CI: -1.04, -0.06; p = 0.02), however, resveratrol had not significant effect on serum concentration of IL-6 (MD = -0.12, 95 % CI: -0.52, 0.27; p = 0.53), in patients with CVDs.

Conclusion: Our results suggest that resveratrol can be used as a potential treatment in patients with CVD by reducing inflammatory conditions.

Keywords: CRP; Cardiovascular disease; Inflammation; Resveratrol; TNF-α.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Anti-Inflammatory Agents
  • Biomarkers
  • Cardiovascular Diseases*
  • Dietary Supplements
  • Humans
  • Inflammation
  • Interleukin-6
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Tumor Necrosis Factor-alpha

Substances

  • Anti-Inflammatory Agents
  • Biomarkers
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Resveratrol