FADS cluster variants are associated with insulin sensitivity in children and adolescents with overweight and obesity

Eur J Clin Nutr. 2022 Dec;76(12):1776-1778. doi: 10.1038/s41430-022-01187-2. Epub 2022 Jul 29.

Abstract

Changes in the desaturation activity of LC-PUFAs may influence insulin sensitivity by modulating the relative abundance of omega-3. The aim of this cross-sectional study was to assess the association between genetic variants of fatty acid desaturase cluster genes (FADS1, FADS2, FADS3) and insulin sensitivity in a cohort of children and adolescents with obesity. Anthropometric evaluation, lipid profile, glucose metabolism parameters and the genotype of rs1535 on FADS2 gene were assessed. In 162 obese children and adolescents (12.6 ± 2.3 years; BMI 30.9 ± 7.3), we found a significant association between an index of insulin sensitivity, i.e., Matsuda index, and rs1535 (B = -0,192; p = 0.008), BMI (B = -0,003; p < 0.001), and triglycerides (B = -0,034; p < 0.001), independent of age and sex [R² = 0.35; p = <0.001]. In conclusion, FADS cluster variants were associated with insulin sensitivity in a population of children and adolescents with obesity, contributing to identify individuals who may benefit from personalised prevention and treatment nutritional strategies since childhood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Cross-Sectional Studies
  • Delta-5 Fatty Acid Desaturase
  • Fatty Acid Desaturases / genetics
  • Genetic Variation
  • Humans
  • Insulin Resistance* / genetics
  • Overweight / genetics
  • Pediatric Obesity* / genetics

Substances

  • Delta-5 Fatty Acid Desaturase
  • Fatty Acid Desaturases
  • FADS1 protein, human
  • FADS2 protein, human
  • FADS3 protein, human