Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun 27;8(6):FSO803.
doi: 10.2144/fsoa-2022-0020. eCollection 2022 Jul.

The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence

Affiliations

The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence

Sk Sujitha Priya et al. Future Sci OA. .

Abstract

Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-κB, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.

Keywords: NF-κB; bioactive compounds; cytokines; dextran sodium sulfate; guggulsterone; inflammatory bowel disease; intestinal epithelial cells; preclinical studies; ulcerative colitis.

PubMed Disclaimer

References

    1. Ahmad MA, Mujeeb M, Akhtar M, Khushtar M, Arif M, Haque MR. Guggulipid: a promising multi-purpose herbal medicinal agent. Drug Res. 70(4), 123–130 (2020). - PubMed
    1. Yamada T, Sugimoto K. Guggulsterone and its role in chronic diseases. Adv. Exp. Med. Biol. 929, 329–361 (2016). - PubMed
    1. Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct. Target Ther. 2, 17023 (2017). - PMC - PubMed
    1. Neurath MF, Becker C, Barbulescu K. Role of NF-κB in immune and inflammatory responses in the gut. Gut 43(6), 856–860 (1998). - PMC - PubMed
    1. Zhang J-M, An J. Cytokines, inflammation, and pain. Int. Anesthesiol. Clin. 45(2), 27–37 (2007). - PMC - PubMed

LinkOut - more resources