The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence
- PMID: 35909996
- PMCID: PMC9327637
- DOI: 10.2144/fsoa-2022-0020
The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence
Abstract
Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-κB, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.
Keywords: NF-κB; bioactive compounds; cytokines; dextran sodium sulfate; guggulsterone; inflammatory bowel disease; intestinal epithelial cells; preclinical studies; ulcerative colitis.
© 2022 The Authors.
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