The Role of T Helper 22 Cells in Dermatological Disorders

Yu Pan; Dan Du; Lian Wang; Xiaoyun Wang; Gu He; Xian Jiang

doi:10.3389/fimmu.2022.911546

The Role of T Helper 22 Cells in Dermatological Disorders

Front Immunol. 2022 Jul 14:13:911546. doi: 10.3389/fimmu.2022.911546. eCollection 2022.

Authors

Yu Pan^{1

2}, Dan Du¹, Lian Wang¹, Xiaoyun Wang^{1

3

4}, Gu He^{1

3

4}, Xian Jiang^{1

3

4}

Affiliations

¹ Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
² Department of Dermatology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
³ Laboratory of Dermatology, China Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
⁴ State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

Abstract

T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway.

Keywords: IL-22; Th22 cells; inflammation; keratinocyte; skin.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes*
Keratinocytes
T-Lymphocytes, Helper-Inducer*