Role of Caveolin-1 in Sepsis - A Mini-Review

Front Immunol. 2022 Jul 15;13:902907. doi: 10.3389/fimmu.2022.902907. eCollection 2022.

Abstract

Sepsis is a generalized disease characterized by an extreme response to a severe infection. Moreover, challenges remain in the diagnosis, treatment and management of septic patients. In this mini-review we demonstrate developments on cellular pathogenesis and the role of Caveolin-1 (Cav-1) in sepsis. Studies have shown that Cav-1 has a significant role in sepsis through the regulation of membrane traffic and intracellular signaling pathways. In addition, activation of apoptosis/autophagy is considered relevant for the progression and development of sepsis. However, how Cav-1 is involved in sepsis remains unclear, and the precise mechanisms need to be further investigated. Finally, the role of Cav-1 in altering cell permeability during inflammation, in sepsis caused by microorganisms, apoptosis/autophagy activation and new therapies under study are discussed in this mini-review.

Keywords: apoptosis; autophagy; caveolin 1; cellular permeability; sepsis.

Publication types

  • Review

MeSH terms

  • Autophagy / physiology
  • Caveolin 1* / genetics
  • Caveolin 1* / metabolism
  • Humans
  • Permeability
  • Sepsis* / genetics
  • Sepsis* / metabolism
  • Signal Transduction

Substances

  • Caveolin 1