An Intelligent Nanomachine Guided by DNAzyme Logic System for Precise Chemodynamic Therapy

Zhao Wang; Jie Yang; Geng Qin; Chuanqi Zhao; Jinsong Ren; Xiaogang Qu

doi:10.1002/anie.202204291

An Intelligent Nanomachine Guided by DNAzyme Logic System for Precise Chemodynamic Therapy

Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202204291. doi: 10.1002/anie.202204291. Epub 2022 Aug 17.

Authors

Zhao Wang^{1

2}, Jie Yang^{1

2}, Geng Qin^{1

2}, Chuanqi Zhao^{1

2}, Jinsong Ren^{1

2}, Xiaogang Qu^{1

2}

Affiliations

¹ Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun, Jilin, 130022, P. R. China.
² University of Science and Technology of China Hefei, Anhui, 230026, P. R. China.

PMID: 35912893
DOI: 10.1002/anie.202204291

Abstract

The intelligent nanomachine usually has a control center to carry out self-regulation. Unfortunately, most of the nanomaterials for chemodynamic therapy (CDT) do not have such a control center to sense and process the chemical or biological signals, which greatly weakens the selectivity and efficiency of CDT. To address this problem, here an intelligent nanomachine was constructed with a DNAzyme logic gate as the control center, and metal organic framework as the actuator. The well-designed nanomachine showed an enhanced killing effect on cancer cells but posed no harm to normal cells, acquiring better selectivity than clinical chemotherapy drugs (doxorubicin and cisplatin). To the best of our knowledge, this is the first reported cell-specific CDT by the guidance of DNAzyme logic gate. Our work highlights the great potential of DNAzymes in intelligent response networks, and extends the implementation of nanomachines in precision medicine.

Keywords: Chemodynamic Therapy; DNAzyme; Nanomachine; Precision Medicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA, Catalytic*
Logic

Substances

DNA, Catalytic