In IBS, a smartphone application for self-managing a FODMAP-lowering diet vs. otilonium bromide reduced symptoms at 8 wk

Ann Intern Med. 2022 Aug;175(8):JC91. doi: 10.7326/J22-0059. Epub 2022 Aug 2.


Carbone F, Van den Houte K, Besard L, et al. Diet or medication in primary care patients with IBS: the DOMINO study-a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute. Gut. 2022. [Epub ahead of print]. 35483886.

Publication types

  • Comment

MeSH terms

  • Diet
  • Diet, Carbohydrate-Restricted
  • Humans
  • Irritable Bowel Syndrome* / diagnosis
  • Irritable Bowel Syndrome* / drug therapy
  • Quaternary Ammonium Compounds
  • Self-Management*
  • Smartphone*


  • Quaternary Ammonium Compounds
  • octylonium