cGAS-STING and the deadly CIN: how chronic inflammation represents a therapeutic vulnerability in chromosomally unstable cancers

Trends Cancer. 2022 Oct;8(10):788-789. doi: 10.1016/j.trecan.2022.07.006. Epub 2022 Jul 29.

Abstract

Chromosomal instability (CIN) is a key genomic driver of human cancer. CIN generates genomic copy-number heterogeneity and tumor-derived inflammation. In a recent paper, Hong et al. identify the cGAS-STING innate immune pathway as a crucial dependency in cancer cells with CIN and pinpoint the IL6/STAT3 axis as a therapeutic vulnerability in these difficult-to-treat tumors.

Publication types

  • Comment

MeSH terms

  • Chromosomal Instability / genetics
  • Humans
  • Inflammation / genetics
  • Interleukin-6* / genetics
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / therapy
  • Nucleotidyltransferases / genetics
  • Nucleotidyltransferases / metabolism

Substances

  • Interleukin-6
  • Nucleotidyltransferases