Abstract
A significant body of experimental evidence supports the notion that a deficiency of either vitamin B12 or folic acid enhances the activity of various carcinogens. Unifying mechanisms are proposed to explain this cocarcinogenic role.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Carcinogens*
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Diet
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Folic Acid / metabolism
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Folic Acid Deficiency / complications*
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Humans
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Methionine / metabolism
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Neoplasms / etiology*
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Neoplasms, Experimental / etiology*
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Neoplasms, Experimental / pathology
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Vitamin B 12 Deficiency / complications*
Substances
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Carcinogens
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Folic Acid
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Methionine