Management of non-renal manifestations of systemic lupus erythematosus: A systematic literature review for the APLAR consensus statements

Int J Rheum Dis. 2022 Nov;25(11):1220-1229. doi: 10.1111/1756-185X.14413. Epub 2022 Aug 2.


The prevalence of systemic lupus erythematosus (SLE) is higher in Asians than Caucasians, with higher frequency of renal and other major organ manifestations that carry a poorer prognosis. The outcome of SLE is still unsatisfactory in many parts of the Asia Pacific region due to limited access to healthcare systems, poor treatment adherence and adverse reactions to therapies. The Asia Pacific League of Associations for Rheumatology (APLAR) SLE special interest group has recently published a set of consensus recommendation statements for the management of SLE in the Asia Pacific region. The current article is a supplement of systematic literature search (SLR) to the prevalence and treatment of non-renal manifestations of SLE in Asian patients.

Keywords: lupus; neuropsychiatric; non-renal; prognosis; severe.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Asia / epidemiology
  • Asian People
  • Humans
  • Kidney
  • Lupus Erythematosus, Systemic* / epidemiology
  • Rheumatology*