Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma

Dermatol Surg. 2022 Aug 1;48(8):797-801. doi: 10.1097/DSS.0000000000003506. Epub 2022 Jun 21.


Background: Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.

Objective: To explore the clinical features and prognosis of young and middle-aged adults with SAC.

Materials and methods: Patients with skin SAC between ages 18 and 59 years from the Surveillance, Epidemiology, and End Results database (1975-2016) were eligible for this study.

Results: Seven hundred thirty-nine cases were identified. The proportion of extraocular SAC in the nonelderly increased from 1975-2005 to 2006-2016 ( p = .001), male predominance was observed in overall patients whereas female predominance in Asian population, and young patients had more head and neck SAC than middle-aged patients ( p = .014). The prognosis of young patients was better than middle-aged patients ( p = .004). Other independent prognostic factors included sex, marital status, tumor size, surgery, chemotherapy, and multiple primary cancer history.

Conclusion: An increasing proportion of extraocular SAC was observed in young and middle-aged patients, and the young developed more head and neck SAC than the middle-aged. Female predominance was found in Asian population, and female patients had better prognosis. Younger age and married status indicated better prognosis, and around 20% of young and middle-aged patients might have poorer survival because of Muir-Torre syndrome.

MeSH terms

  • Adenocarcinoma, Sebaceous* / pathology
  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muir-Torre Syndrome*
  • Prognosis
  • Sebaceous Gland Neoplasms* / epidemiology
  • Sebaceous Gland Neoplasms* / pathology
  • Sebaceous Gland Neoplasms* / therapy
  • Skin / pathology
  • Young Adult