Targeting disrupted rich-club network organization with neuroplasticity-based computerized cognitive remediation in major depressive disorder patients

Min Shu; Suyang Feng; Jiacheng Liu

doi:10.1016/j.psychres.2022.114742

Targeting disrupted rich-club network organization with neuroplasticity-based computerized cognitive remediation in major depressive disorder patients

Psychiatry Res. 2022 Oct:316:114742. doi: 10.1016/j.psychres.2022.114742. Epub 2022 Jul 27.

Authors

Min Shu¹, Suyang Feng², Jiacheng Liu³

Affiliations

¹ Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.
² Department of Radiology, The Affiliated Jiangning Hospital of Nanjing Medical University, No.168, gushan Road, Nanjing, Jiangsu 211100, China.
³ Department of Nuclear Medicine, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China. Electronic address: jiachengliu@seu.edu.cn.

PMID: 35917652
DOI: 10.1016/j.psychres.2022.114742

Abstract

Disrupted rich-club organization has been extensively studied in major depressive disorder (MDD) patients. Although data indicate that neuroplasticity-based computerized cognitive remediation (nCCR) can accelerate clinical responses in MDD patients, the mechanisms underlying its antidepressant efficacy are unknown. In this study, all MDD patients underwent two (baseline and week 4) neuropsychological assessments and DTI imaging. Additionally, 17 MDD patients did nCCR for 30 hours spread across 4 weeks. Rich-club organization was calculated with a graph-theoretical approach, and SC-FC coupling was explored. After 4 weeks of treatment, the number of rich-club connections, global efficiency, and SC-FC coupling strength increased significantly and were negatively associated with TMT-B scores. The effects of nCCR on disrupted rich-club organization may partly underlie its efficacy in improving the executive function of patients with MDD. Effects of nCCR on disrupted rich-club organization may partly underlie its efficacy in improving the executive function of patients with MDD.

Keywords: Brain structural connectome; Cognitive training; Major depressive disorder; Network efficiency; Rich club organization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain
Cognitive Remediation*
Connectome* / methods
Depressive Disorder, Major* / drug therapy
Depressive Disorder, Major* / therapy
Diffusion Tensor Imaging
Humans
Magnetic Resonance Imaging
Neural Pathways / diagnostic imaging
Neuronal Plasticity