Sleep Problems in Children With Neurocutaneous Syndromes: A Cross-Sectional Study

J Child Neurol. 2022 Oct;37(10-11):864-870. doi: 10.1177/08830738221114560. Epub 2022 Aug 2.


Introduction: The prevalence and patterns of sleep disturbances in neurocutaneous syndromes are variable and understudied. Methods: Cross-sectional study for 18 months at a tertiary care pediatric hospital, involving 100 children with neurocutaneous syndromes aged between 4 and 10 years using the Children's Sleep Habits Questionnaire-Abbreviated. Results: In 100 children with neurocutaneous syndromes, 47 (47%) had significant sleep problems. In subgroup analysis, 7 of 17 children with neurofibromatosis 1, 24 of 63 children with tuberous sclerosis complex, 10 of 12 children with Sturge-Weber syndrome, 2 of 3 children with linear nevus sebaceous syndrome, and each of the children with hypomelanosis of Ito, McCune-Albright syndrome, megalencephaly-capillary malformation syndrome, and unclassified neurocutaneous syndrome had significant sleep problems. Conclusion: The prevalence of sleep problems in our study population was not more than that observed in the general pediatric population. Prospective multicentric studies are needed to comprehend sleep problems in children with neurocutaneous syndromes.

Keywords: Children’s Sleep Habits Questionnaire; Neurocutaneous syndromes; Sleep problems.

MeSH terms

  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Humans
  • Neurocutaneous Syndromes* / complications
  • Neurocutaneous Syndromes* / epidemiology
  • Prospective Studies
  • Sleep Wake Disorders* / epidemiology
  • Sturge-Weber Syndrome*
  • Tuberous Sclerosis* / complications
  • Tuberous Sclerosis* / epidemiology