Xanthoma of the temporal bone and skull base

Am J Otol. 1987 Mar;8(2):111-5.


Xanthomata are soft tissue tumors composed of lipid-laden "foamy" histiocytes associated with cholesterol clefts and inflammation. They are considered to be specialized granuloma rather than true neoplasms and are usually associated with disorders of lipid metabolism, most commonly one of the hyperlipoproteinemia syndrome. A rare case of a xanthoma involving the temporal bone and causing extensive destruction of the skull base is presented. Otalgia and infection are the most common presenting symptoms of this disorder, with multiple cranial nerve palsies resulting in some cases. Treatment includes conservative surgical debulking, dietary restriction of fat and cholesterol, and pharmacologic reduction of serum lipids.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carotid Artery, Internal / diagnostic imaging
  • Humans
  • Hypercholesterolemia / complications
  • Male
  • Skull / diagnostic imaging
  • Skull / pathology*
  • Temporal Bone / diagnostic imaging
  • Temporal Bone / pathology*
  • Tomography, X-Ray Computed
  • Xanthomatosis / complications
  • Xanthomatosis / diagnostic imaging
  • Xanthomatosis / pathology*