Clinical, virological, imaging and pathological findings in a SARS CoV-2 antibody positive cat

J Vet Sci. 2022 Jul;23(4):e52. doi: 10.4142/jvs.21310.


This paper reports a presumptive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a cat. A cat with respiratory disease living with three individuals with coronavirus disease 2019 showed bilateral ground-glass opacities in the lung on X-ray and computed tomography. The clinical swabs were negative for SARS-CoV-2 RNA, but the serum was positive for SARS-CoV-2 antibodies. Interstitial pneumonia and prominent type 2 pneumocyte hyperplasia were noted on histopathology. Respiratory tissues were negative for SARS-CoV-2 RNA or antigen, but the cat was positive for feline parvovirus DNA. In conclusion, the respiratory disease and associated pathology in this cat could have been due to exposure to SARS-CoV-2.

Keywords: Cat; SARS-CoV-2; X-ray; antibody; ground-glass opacity; interstitial pneumonia; tomography.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antibodies, Viral
  • COVID-19* / veterinary
  • Cat Diseases* / diagnostic imaging
  • Cats
  • RNA, Viral
  • SARS-CoV-2
  • Tomography, X-Ray Computed / veterinary


  • Antibodies, Viral
  • RNA, Viral