A comprehensive review of recent advances in the biological activities of quinazolines

Chem Biol Drug Des. 2022 Nov;100(5):639-655. doi: 10.1111/cbdd.14129. Epub 2022 Aug 12.

Abstract

Quinazoline heterocycles are critical in the development of medications. Quinazoline derivatives have been intensively researched, providing a wide range of compounds with diverse biological roles. The quinazoline nucleus has garnered a lot of attention in medical chemistry in recent years. It was assumed to be a pharmacophore component in the development of physiologically interesting drugs. This review is an attempt to increase the potential of quinazoline by highlighting a wide range of advancements demonstrated by numerous derivatives of the quinazoline moiety, as well as focusing on diverse pharmacological actions of the quinazoline moiety. This review compiles recent studies on the quinazoline moiety described in the literature by researchers.

Keywords: anti-Alzheimer; anticancer; biology; design; diabetic; quinazoline.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Quinazolines* / chemistry

Substances

  • Quinazolines