Susceptibility genes of hyperuricemia and gout

Hereditas. 2022 Aug 4;159(1):30. doi: 10.1186/s41065-022-00243-y.


Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most important risk factor for gout. In recent years, with the improvement of living standards and the change of dietary habits, the incidence of gout in the world has increased dramatically, and gradually tends to be younger. An increasing number of studies have shown that gene mutations may play an important role in the development of HUA and gout. Therefore, we reviewed the existing literature and summarized the susceptibility genes and research status of HUA and gout, in order to provide reference for the early diagnosis, individualized treatment and the development of new targeted drugs of HUA and gout.

Keywords: Gout; Hyperuricemia; Serum uric acid; Single nucleotide polymorphism; Susceptibility gene.

Publication types

  • Review

MeSH terms

  • Gout* / drug therapy
  • Gout* / genetics
  • Humans
  • Hyperuricemia* / genetics
  • Mutation
  • Risk Factors
  • Uric Acid


  • Uric Acid