Osteoarthritis is the most common type of arthritis. Nowadays, it can no longer be undertstood as a singularly abrasive and mechanical disease. With time, unveiling its mechanisms to the molecular aspect brings us close to the full comprehension of its diversity and syndrome-like behavior. Reinforcing the propagation of the updated scientific knowledge and changing the underlying mentalities will serve as a fast track to the better integration of this disease. Rightfully treating this epidemic is of the utmost relevance.