Highly Divergent SARS-CoV-2 Alpha Variant in Chronically Infected Immunocompromised Person

Emerg Infect Dis. 2022 Sep;28(9):1920-1923. doi: 10.3201/eid2809.220875. Epub 2022 Aug 4.


We detected a highly divergent SARS-CoV-2 Alpha variant in an immunocompromised person several months after the latest detection of the Alpha variant in the Netherlands. The patient was infected for 42 weeks despite several treatment regimens and disappearance of most clinical symptoms. We identified several potential immune escape mutations in the spike protein.

Keywords: Alpha variant; COVID-19; SARS-CoV-2; coronavirus disease; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; the Netherlands; variants; virus evolution; viruses; zoonoses.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / immunology
  • Humans
  • Immunocompromised Host
  • Mutation*
  • Netherlands
  • SARS-CoV-2* / classification
  • SARS-CoV-2* / genetics
  • SARS-CoV-2* / immunology
  • Spike Glycoprotein, Coronavirus / genetics


  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2

Supplementary concepts

  • SARS-CoV-2 variants