Monoclonal antibody CC3C195, which detects cancer-associated antigens in serum, binds to the human Lea blood group antigen and to its sialylated derivative

S Fukuta; J L Magnani; P K Gaur; V Ginsburg

doi:10.1016/0003-9861(87)90314-6

Monoclonal antibody CC3C195, which detects cancer-associated antigens in serum, binds to the human Lea blood group antigen and to its sialylated derivative

Arch Biochem Biophys. 1987 May 15;255(1):214-6. doi: 10.1016/0003-9861(87)90314-6.

Authors

S Fukuta, J L Magnani, P K Gaur, V Ginsburg

PMID: 3592664
DOI: 10.1016/0003-9861(87)90314-6

Abstract

Mouse monoclonal antibody CC3C195, which detects elevated levels of its antigen in sera from many patients with colon and pancreatic cancer, binds with high affinity to the sialylated human Lea blood group antigen NeuAc alpha 2-3Gal beta 1-3 [Fuc alpha 1-4]GlcNac . . . and with lower affinity to the Lea blood group antigen itself.

MeSH terms

Animals
Antibodies, Monoclonal*
Antibody Specificity
Antigen-Antibody Reactions*
Antigens, Neoplasm / immunology
Humans
Isoantigens / immunology*
Lewis Blood Group Antigens / immunology*
Mice
Mice, Inbred BALB C

Substances

Antibodies, Monoclonal
Antigens, Neoplasm
Isoantigens
Lewis Blood Group Antigens