SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany

Marian Rewers; Ezio Bonifacio; Dominik Ewald; Cristy Geno Rasmussen; Xiaofan Jia; Laura Pyle; Anette-Gabriele Ziegler; ASK Study Group and Fr1da Study Group

doi:10.1001/jama.2022.14092

SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents From Colorado, USA, and Bavaria, Germany

JAMA. 2022 Sep 27;328(12):1252-1255. doi: 10.1001/jama.2022.14092.

Authors

Marian Rewers¹, Ezio Bonifacio², Dominik Ewald³, Cristy Geno Rasmussen¹, Xiaofan Jia¹, Laura Pyle¹, Anette-Gabriele Ziegler⁴; ASK Study Group and Fr1da Study Group

Affiliations

¹ Barbara Davis Center for Diabetes, University of Colorado, Aurora.
² Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany.
³ Berufsverband der Kinder-und Jugendärzte eV, Landesverband Bayern, Regensburg, Germany.
⁴ Institute of Diabetes Research Helmholtz Munich, German Research Center for Environmental Health, Munich, Germany.

No abstract available

Plain language summary

This study screens more than 50 000 youths in diverse populations of Colorado and Bavaria to assess whether previous SARS-CoV-2 infection was associated with autoimmunity, which predicts future type 1 diabetes.

MeSH terms

Adolescent
Asymptomatic Diseases / epidemiology
Autoimmunity
COVID-19* / epidemiology
Child
Colorado / epidemiology
Diabetes Mellitus, Type 1* / epidemiology
Diabetes Mellitus, Type 1* / immunology
Germany / epidemiology
Humans
SARS-CoV-2

Grants and funding

P30 DK116073/DK/NIDDK NIH HHS/United States