Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease

Blood. 2022 Nov 24;140(21):2300-2304. doi: 10.1182/blood.2021015178.


Previous studies suggest that gut microbiome disruption induced by chemotherapy, dietary deficiencies, and/or antibiotics are associated with increased incidence of acute graft-versus-host disease (aGVHD) following hematopoietic stem cell transplantation (HSCT). In a murine model of antibiotic-induced gut microbiome disruption, Holmes and colleagues show that oral administration of galactooligosaccharides (GOS) as a prebiotic attenuates lethal aGVHD, highlighting the crosstalk between diet and gut microbiota. Their data encourage clinical trials of GOS prebiotic diets during HSCT.

MeSH terms

  • Animals
  • Gastrointestinal Microbiome*
  • Graft vs Host Disease* / prevention & control
  • Mice
  • Prebiotics


  • Prebiotics