Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells

Cell Stem Cell. 2022 Aug 4;29(8):1156-1158. doi: 10.1016/j.stem.2022.07.002.


In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes the notion that the cumulative inflammatory events over the course of an organism's lifespan may irreversibly damage LT-HSCs.

Publication types

  • Comment

MeSH terms

  • Aging*
  • Hematopoietic Stem Cells*
  • Humans
  • Inflammation