RAPID Aneurysm: Artificial intelligence for unruptured cerebral aneurysm detection on CT angiography

J Stroke Cerebrovasc Dis. 2022 Oct;31(10):106690. doi: 10.1016/j.jstrokecerebrovasdis.2022.106690. Epub 2022 Aug 4.


Objectives: Cerebral aneurysms may result in significant morbidity and mortality. Identification of these aneurysms on CT Angiography (CTA) studies is critical to guide patient treatment. Artificial intelligence platforms to assist with automated aneurysm detection are of high interest. We determined the performance of a semi-automated artificial intelligence software program (RAPID Aneurysm) for the detection of cerebral aneurysms.

Materials and methods: RAPID Aneurysm was used to detect retrospectively the presence of cerebral aneurysms in CTA studies performed between January 2019 and December 2020. The gold standard was aneurysm presence and location as determined by the consensus of three expert neuroradiologists. Aneurysm detection accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and positive and negative likelihood ratios by RAPID Aneurysm were determined.

Results: 51 patients (mean age, 56±15; 24 women [47.1%]) with a single CTA were included. A total of 60 aneurysms were identified. RAPID Aneurysm had a sensitivity of 0.950 (95% CI: 0.863-0.983), specificity of 1.000 (95% CI: 0.996-1.000), a positive predictive value (PPV) of 1.000 (95% CI: 0.937-1.000), a negative predictive value (NPV) of 0.997 (95% CI: 0.991-0.999), and an accuracy of 0.997 (95% CI: 0.991-0.999) for cerebral aneurysm detection.

Conclusions: RAPID Aneurysm is highly accurate for the detection of cerebral aneurysms on CTA.

Keywords: AI; Aneurysm; Artificial intelligence; Brain; Cerebral.

MeSH terms

  • Adult
  • Aged
  • Angiography, Digital Subtraction
  • Artificial Intelligence
  • Cerebral Angiography
  • Computed Tomography Angiography
  • Female
  • Humans
  • Intracranial Aneurysm* / diagnostic imaging
  • Middle Aged
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed