Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population

Baoping Hu; Yuhe Wang; Zhongtao Wang; Xue He; Li Wang; Dongya Yuan; Yongjun He; Tianbo Jin; Shumei He

doi:10.3389/fgene.2022.899124

Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population

Front Genet. 2022 Jul 22:13:899124. doi: 10.3389/fgene.2022.899124. eCollection 2022.

Authors

Baoping Hu^{1

2

3

4}, Yuhe Wang^{1

2

3

5}, Zhongtao Wang⁶, Xue He^{1

2

3}, Li Wang^{1

2

3}, Dongya Yuan^{1

2

3}, Yongjun He^{1

2

3}, Tianbo Jin^{1

2

3}, Shumei He^{1

2

3}

Affiliations

¹ Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.
² Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, Xianyang, China.
³ Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang, China.
⁴ Department of Anesthesiology, The Affiliated Hospital of Xizang Minzu University, Xianyang, China.
⁵ Department of Clinical Laboratory, The Affiliated Hospital of Xizang Minzu University, Xianyang, China.
⁶ Department of Infectious Diseases, General Hospital of Tibet Military Command, Lhasa, China.

Abstract

Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the SLC11A1 gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12-2.56, p = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08-2.41, p = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04-2.65, p = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (p = 0.012) and age >41 group (p = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (p = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the SLC11A1 gene and age- and sex-specific TB risk in the northwest Chinese Han population.

Keywords: SLC11A1; case-control; polymorphism; susceptibility; tuberculosis.