Skin manifestations of pancreatic diseases

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022 Dec;166(4):353-358. doi: 10.5507/bp.2022.035. Epub 2022 Jul 22.


Although symptoms of pancreatic diseases such as pancreatitis, acute and chronic and, carcinoma of the pancreas are mainly gastrointestinal in nature, the extra-pancreatic symptoms are also important. These include skin symptoms, such as pancreatic panniculitis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema, cutaneous signs of hemorrhage, as in persons with severe acute pancreatitis, or the finding of cutaneous metastases of pancreatic carcinoma, which may be a sign of advanced disease. The pancreas is therefore one of those organs for which diagnosis and therapy are often multidisciplinary. In this review article, we summarize current knowledge of the possible skin manifestations of pancreatic disorders.

Keywords: acanthosis nigricans; acute pancreatitis; chronic pancreatitis; livedo reticularis; necrolytic migratory erythema; pancreatic cancer; pancreatic panniculitis; skin lesions.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Humans
  • Pancreatic Diseases* / complications
  • Pancreatic Diseases* / pathology
  • Pancreatic Neoplasms* / complications
  • Pancreatitis* / etiology
  • Skin
  • Skin Diseases* / etiology